T-cell receptor gene rearrangement

T-cell receptor gene rearrangement is a process that enables T cells, a type of immune cell, to recognize a wide variety of pathogens. In developing T cells, specific gene segments called V (Variable), D (Diversity), and J (Joining) segments are shuffled and joined in different combinations. This genetic reshuffling creates unique receptors on each T cell’s surface, allowing the immune system to detect many different invaders. This process ensures a diverse arsenal of T cells, each capable of recognizing specific threats, which is essential for a robust immune defense.