store-operated calcium entry (SOCE)

Store-operated calcium entry (SOCE) is a process cells use to replenish calcium levels inside them. When calcium stores within a cell’s internal compartments are low, specialized sensors detect this depletion. These sensors then trigger calcium channels on the cell’s surface membrane to open, allowing calcium from outside the cell to flow in. This influx helps maintain essential cellular functions, such as communication, muscle contraction, and signal processing. SOCE acts as a feedback mechanism ensuring cells have enough calcium to perform their activities effectively.