Star*D Protocol

The STAR*D protocol was a large study designed to find the most effective way to treat depression. It tested different antidepressant medications and treatment strategies, aiming to help patients who didn't improve with initial treatment. If the first medication didn't work, doctors would try another, sometimes combining drugs or adjusting doses. The study showed that many patients need multiple treatment attempts to find relief and that personalized care and persistence are key. Overall, STAR*D provided valuable insights into how best to manage depression in real-world settings.