Sporadic Fatal Insomnia (sFI)

Sporadic Fatal Insomnia (sFI) is a rare, prion-related neurological disorder that affects the brain's ability to regulate sleep. Unlike typical insomnia, sFI causes severe sleep disturbances, leading to total inability to sleep over time. As the condition progresses, it results in significant cognitive decline, loss of coordination, and physical deterioration. It is caused by abnormal proteins called prions that damage brain cells. sFI is considered fatal, with patients often succumbing within months to a few years after symptoms begin. There's currently no cure, making it a particularly concerning and mysterious condition within prion diseases.