solid-phase peptide synthesis

Solid-phase peptide synthesis (SPPS) is a method used to create proteins by sequentially linking amino acids—the building blocks of proteins—on a solid support, like a resin bead. Starting with one amino acid attached to the bead, new amino acids are added step-by-step, with protective groups that prevent unwanted reactions. After each addition, excess reagents are washed away, allowing precise assembly of the desired peptide chain. Once complete, the peptide is detached from the solid support, purified, and used for research or therapeutic purposes. This technique allows efficient, automated production of specific peptides with high accuracy.