Skin Permeation

Skin permeation refers to the process by which substances pass through the skin's layers and enter the body. The skin acts as a barrier, primarily through its outermost layer, the stratum corneum. Factors affecting permeation include the substance’s chemical properties, skin condition, and contact duration. Understanding permeation is important in designing topical medications, skincare products, and assessing exposure risks. Essentially, it describes how well a substance can penetrate the skin to reach the underlying tissues or bloodstream, influencing their effectiveness or safety.