SIx2 (senescence indicator)

Six2 is a transcription factor involved in the development of certain tissues, but in the context of aging, SIX2 can serve as a biomarker linked to cellular aging processes. Specifically, its expression levels can indicate the presence of senescent cells—cells that have stopped dividing and contribute to tissue aging and decline. Detecting SIX2 helps researchers understand cellular aging mechanisms and how tissues deteriorate over time, potentially guiding efforts to diagnose or treat age-related conditions. It’s a useful molecular indicator in research focused on understanding and monitoring the aging process at a cellular level.