Simon's Two-Stage Design

Simon's Two-Stage Design is a method used in clinical trials to efficiently assess whether a new treatment is promising. In the first stage, a small group of patients is treated; if the results are positive enough, the trial moves to the second stage with more patients. If not, the trial stops early to avoid unnecessary steps. This approach helps save time and resources, and protects patients from ineffective treatments by quickly identifying promising options or halting unpromising ones. It balances the need for thorough testing with efficiency and ethical considerations.