SIFT (Sorting Intolerant From Tolerant)

SIFT (Sorting Intolerant From Tolerant) is a computational tool used to predict whether specific genetic variations, called single nucleotide polymorphisms (SNPs), affect how proteins work. It analyzes the DNA changes to determine if they are likely harmless or potentially harmful by assessing the importance of affected parts of the protein across different species. This helps researchers identify which genetic differences might contribute to diseases or impact individual health, guiding further investigation and personalized medicine.