SFC Methods Development

SFC (Supercritical Fluid Chromatography) Methods Development involves creating procedures to effectively separate and analyze complex mixtures using supercritical fluids, typically carbon dioxide at specific temperature and pressure conditions. This process entails selecting the right combination of solvents, additives, and operational parameters to achieve optimal separation, sensitivity, and speed. Method development ensures reliable, reproducible analysis for applications like pharmaceuticals, environmental testing, and food safety. It requires understanding how supercritical fluids interact with different compounds, adjusting parameters accordingly, and validating the method’s performance for accurate, efficient results.