Serotonin 5-HT3 receptor antagonist

A serotonin 5-HT3 receptor antagonist is a medication that blocks specific receptors involved in triggering nausea and vomiting. Serotonin is a chemical in the body that helps regulate many functions, including mood and digestion. When these receptors, particularly the 5-HT3 type, are overly active—such as during chemotherapy or certain illnesses—they can cause nausea and vomiting. By blocking these receptors, the medication reduces these symptoms, providing relief. These drugs are commonly used in patients undergoing cancer treatment or surgery to help prevent nausea and improve comfort.