SERCAs (Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPases)

SERCA proteins are specialized pumps found in the membranes of the sarcoplasmic and endoplasmic reticulum within cells. Their main role is to actively transport calcium ions from the cytoplasm into the storage compartments, using energy from ATP. This process is essential for muscle relaxation and various cellular functions, as it helps regulate calcium levels, which are vital for processes like contraction, signaling, and enzyme activity. Proper SERCA function ensures calcium balance, maintaining healthy cell activity and muscle function.