Scanning Ion Conductance Microscopy (SICM)

Scanning Ion Conductance Microscopy (SICM) is a technique used to create detailed, three-dimensional images of delicate biological samples, such as cells, without damaging them. It works by using a tiny, transparent probe filled with an electrolyte solution that senses electrical conductance changes near the sample surface. As the probe moves close to the sample, the conductance varies, allowing the instrument to map the surface topography with nanometer precision. SICM provides high-resolution images of soft, sensitive structures in their natural state, making it valuable in biological research and nanotechnology.