SAC (Spindle Assembly Checkpoint)

The Spindle Assembly Checkpoint (SAC) is a safety mechanism in cell division that ensures chromosomes are properly aligned and attached to the spindle fibers before the cell proceeds to divide. This checkpoint prevents errors like chromosome missegregation, which can lead to genetic instability. If all chromosomes are correctly attached, SAC is satisfied, allowing the cell to complete division. If not, the checkpoint halts the process, giving the cell time to fix attachment issues. This regulation helps maintain accurate genetic inheritance and prevents abnormalities such as aneuploidy.