Runx2 (Runt-related transcription factor 2)

Runx2, also known as Runt-related transcription factor 2, is a protein that plays a crucial role in bone development. It acts as a gene regulator, turning on specific genes that drive the formation and maturation of bone cells called osteoblasts. By controlling these genes, Runx2 helps ensure bones develop strong and properly shaped. It is essential during the growth phase and in maintaining healthy bones throughout life. Without Runx2, bones may not form correctly, leading to bone disorders such as cleidocranial dysplasia.