Runx2

Runx2 is a protein that acts as a master regulator in the development of bones. It functions as a transcription factor, meaning it helps turn on specific genes necessary for bone formation, guiding precursor cells to become bone cells (osteoblasts). Without Runx2, bones would not develop properly. It plays a critical role during embryonic development and continues to be important for maintaining healthy bones throughout life. Proper regulation of Runx2 ensures bones are strong and correctly formed, while abnormalities can lead to bone diseases or growth issues.