Rejection of Blood Transfusions

Rejection of blood transfusions, known as alloimmunization, occurs when the immune system identifies transfused blood cells as foreign and mistakenly attacks them. This can happen if the donor's blood has different antigens than the recipient's. The immune response may cause complications like fever, hemolysis, or organ problems. Some individuals, due to religious beliefs or personal decisions, choose to refuse blood transfusions. Healthcare providers may then explore alternative treatments, such as medications or techniques to reduce blood loss, to manage medical conditions without transfusing blood.