Reed-Sternberg cells

Reed-Sternberg cells are large, abnormal immune cells that are characteristic of Hodgkin lymphoma, a type of blood cancer. These cells originate from normal white blood cells called lymphocytes but undergo genetic changes that cause them to grow abnormally and multiply uncontrollably. Unlike healthy immune cells, Reed-Sternberg cells often have an unusual appearance, with multiple nuclei or large, owl-like nuclei, making them distinguishable under a microscope. Their presence helps pathologists diagnose Hodgkin lymphoma and guides treatment decisions. Essentially, they are the hallmark cellular abnormality associated with this specific cancer.