receptor activator of nuclear factor kappa-B (RANK)

Receptor activator of nuclear factor kappa-B (RANK) is a protein found on the surface of certain cells, especially those involved in bone remodeling. It plays a key role in regulating bone health by helping bone cells called osteoclasts develop and function, which are responsible for breaking down old or damaged bone. RANK interacts with its partner, RANK ligand (RANKL), to signal osteoclasts to mature and activate. This balance maintains healthy bones; too much RANK activity can lead to bone loss, while controlled activity helps keep bones strong and healthy.