Rb pathway inhibitors

Rb pathway inhibitors are drugs designed to target and block specific molecules involved in the cell cycle regulation controlled by the retinoblastoma (Rb) protein. The Rb pathway helps prevent uncontrolled cell growth by stopping cells from dividing too early. In cancers, this pathway often becomes dysregulated, leading to tumor growth. Inhibitors targeting this pathway work by interfering with proteins that inactivate Rb, restoring its ability to prevent excessive cell division. This makes these drugs valuable in treating certain cancers, especially those with disruptions in the Rb pathway, by halting tumor progression and potentially shrinking tumors.