RAGE

RAGE (Receptor for Advanced Glycation End-products) is a protein found on cell surfaces that detects and responds to harmful molecules called advanced glycation end-products (AGEs), which form when proteins or fats become damaged over time or due to stress. When RAGE binds to AGEs or other molecules associated with inflammation and oxidative stress, it activates internal cell pathways that can lead to inflammation, tissue damage, or cell death. This process is involved in aging and various chronic diseases such as diabetes, Alzheimer’s, and heart disease. In essence, RAGE is a cellular sensor that influences our body's inflammatory and degenerative processes.