RAG1 and RAG2

RAG1 and RAG2 are proteins essential for our immune system, specifically in developing B and T cells that defend against infections. They work together to identify and cut DNA at specific spots in genes that produce antibodies and T-cell receptors. This process rearranges DNA segments, creating a vast variety of unique receptors capable of recognizing many different pathogens. Without RAG1 and RAG2, the immune system cannot generate this diversity, leading to severe immune deficiencies. Their coordinated activity is crucial for the adaptive immune response, providing the flexibility to combat a wide range of diseases.