RAG (Recombination-activating gene)

Recombination-activating genes (RAG) are specialized genes in the immune system that help produce diverse antibodies and T-cell receptors. They do this by editing genetic material in immune cells called lymphocytes, cutting and rejoining DNA segments to create a wide variety of unique receptors. This genetic reshuffling enables the immune system to recognize and respond to an enormous range of pathogens. RAG genes are essential for developing adaptive immunity, first turning on during immune cell development to generate necessary receptor diversity, and are crucial for effective immune defense against infections.