R. A. Fisher's "The Design of Experiments"

R. A. Fisher's "The Design of Experiments" is a foundational work that introduced systematic methods for planning studies to reliably identify cause-and-effect relationships. He emphasized carefully structured experiments using randomization, replication, and control to reduce bias and variability. This approach ensures that results are more accurate and trustworthy, laying the groundwork for modern scientific research across fields like agriculture, medicine, and industry. Essentially, Fisher provided a rigorous framework to design experiments that maximize clarity and reliability while efficiently using resources.