pyrogen testing

Pyrogen testing is a quality control process used to detect fever-causing contaminants, called pyrogens, in medical products like vaccines and injectable drugs. Pyrogens are substances, often from bacteria or fungi, that can trigger fever or other immune responses when introduced into the body. The testing ensures that products are free from these harmful substances, maintaining patient safety. Common methods include the rabbit pyrogen test and the limulus amebocyte lysate (LAL) test, which uses horseshoe crab blood to detect bacterial endotoxins. Overall, pyrogen testing helps confirm that medical products are safe for human use.