Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome

PAPA syndrome is a rare genetic disorder that causes repeated joint inflammation (arthritis), painful skin ulcers called pyoderma gangrenosum, and severe acne. These symptoms result from abnormal immune system responses and inflammation. It typically begins in childhood or adolescence and can cause significant discomfort and skin issues. The condition is inherited and managed with medications that reduce inflammation and immune activity. While challenging, early diagnosis and treatment can help control symptoms and improve quality of life.