Pvalb-Cre mouse model

The Pvalb-Cre mouse model is a genetically engineered research tool used to study specific brain cells called interneurons that produce a protein called parvalbumin. In this model, the gene for the enzyme Cre recombinase is inserted into the parvalbumin gene, so only these interneurons activate Cre. Researchers can then introduce other genetic tools that respond to Cre, allowing precise control or labeling of parvalbumin-expressing neurons. This helps scientists understand their roles in brain function, neural circuits, and behavior, especially in relation to conditions like epilepsy, schizophrenia, and autism.