PTHrP (Parathyroid Hormone-related Protein)

PTHrP (Parathyroid Hormone-related Protein) is a protein that mimics some actions of the parathyroid hormone, helping regulate calcium levels in the body. It is naturally produced in various tissues and plays roles in cell growth and development, especially during fetal development and tissue repair. However, in certain cancers, tumor cells can produce excess PTHrP, which can lead to elevated calcium levels in the blood, a condition called hypercalcemia. This overproduction can cause symptoms like weakness, nausea, and confusion. Understanding PTHrP is important in diagnosing and managing specific medical conditions, particularly related to abnormal calcium regulation.