PSEN2 (Presenilin 2)

PSEN2 (Presenilin 2) is a gene that produces a protein involved in the processing of amyloid precursor protein (APP), which is linked to Alzheimer’s disease. This protein is part of a complex that helps cut APP into smaller pieces; mutations in PSEN2 can lead to abnormal buildup of amyloid plaques in the brain, a hallmark of Alzheimer’s. While most people have healthy versions of PSEN2, inherited mutations can increase the risk of early-onset Alzheimer’s, affecting memory and cognitive functions. Understanding PSEN2 helps researchers explore targeted treatments for Alzheimer’s disease.