Prothrombin 20210A

Prothrombin 20210A is a genetic variation, or mutation, in the gene responsible for producing prothrombin, a protein essential for blood clotting. This mutation involves a small change in the DNA sequence (specifically at position 20210) that can lead to higher levels of prothrombin in the blood. Elevated prothrombin increases the risk of forming abnormal blood clots (thrombosis), which can cause conditions like deep vein thrombosis or pulmonary embolism. Having this mutation does not guarantee clots will develop but does raise the risk, especially when combined with other risk factors such as surgery or immobility.