Protein phosphatase 2B (Calcineurin)

Protein phosphatase 2B, also known as Calcineurin, is an enzyme that plays a crucial role in cell signaling by removing phosphate groups from proteins. This process regulates various cellular functions, especially in the immune system and nervous system. Calcineurin is activated by calcium and calmodulin, helping to turn on specific genes necessary for immune responses and nerve activity. Because of its importance, drugs that inhibit calcineurin, like cyclosporine, are used to suppress immune reactions, such as in organ transplants, preventing rejection.