Propofol Infusion Syndrome

Propofol Infusion Syndrome (PRIS) is a rare but serious complication that can occur with high or prolonged use of the medication propofol, which is commonly used to induce and maintain anesthesia or sedation. It involves symptoms like heart failure, muscle breakdown, kidney failure, and metabolic abnormalities. PRIS may develop quickly and requires prompt medical attention. Although uncommon, the risk increases with higher doses or long-term infusions. Healthcare providers monitor closely to balance effective sedation with safety, adjusting dosages as needed to prevent this serious complication.