positive allosteric modulation

Positive allosteric modulation occurs when a substance binds to a specific site on a receptor, different from where the primary active molecule (like a neurotransmitter) binds. This binding enhances the receptor's response to the active molecule, making it more effective without directly activating the receptor itself. It acts like a volume knob, increasing the receptor's sensitivity and activity when needed. This mechanism allows for more precise regulation of biological responses, potentially leading to fewer side effects compared to directly activating the receptor with drugs.