PMCA

PMCA (Protein Misfolding Cyclic Amplification) is a laboratory technique used to detect very small amounts of misfolded proteins associated with neurodegenerative diseases like Creutzfeldt-Jakob disease. It works by taking a tiny sample that may contain these abnormal proteins and mixing it with normal, healthy proteins. Through cycles of incubation and shaking, the misfolded proteins encourage the normal ones to also become misfolded, amplifying their presence. This process allows scientists to identify the disease-associated proteins more easily and quickly, aiding diagnosis and research into these conditions.