PKA inhibitors

PKA inhibitors are substances that block the activity of Protein Kinase A (PKA), an enzyme involved in regulating various cellular processes like metabolism, gene expression, and cell growth. PKA becomes active when a molecule called cyclic AMP (cAMP) binds to it, leading to the phosphorylation of target proteins. Inhibitors prevent PKA from attaching phosphate groups to these proteins, thereby modulating their activity. scientists use PKA inhibitors to study how cells respond to signals and may develop them into therapies for diseases where PKA activity is abnormal, such as certain cancers or metabolic disorders.