PICALM (Phosphatidylinositol Binding Clathrin-Acidi

PICALM (Phosphatidylinositol Binding Clathrin-Assembly Protein) is a protein involved in the process of cellular "cleanup." It helps cells internalize and recycle materials from their surface by guiding clathrin, a protein that forms coated pits and vesicles for transport. PICALM binds to specific lipids in cell membranes, facilitating the formation of vesicles that carry nutrients, signals, or waste inside the cell. Its proper function is important for cellular health and communication, and variations in PICALM have been linked to an increased risk of Alzheimer's disease and other neurological conditions.