Phase I detoxification

Phase I detoxification is the body's initial process for preparing harmful substances, like toxins or drugs, for elimination. It involves chemical reactions, mainly oxidation, reduction, or hydrolysis, which modify these substances to make them more water-soluble. Enzymes, particularly from the cytochrome P450 family, facilitate these reactions in the liver. Sometimes, this process creates reactive intermediate compounds that can be more toxic, so Phase I is often followed by Phase II, which safely attaches molecules to these intermediates for easier removal from the body. Overall, Phase I is essential for neutralizing and preparing toxins for elimination.