Pharmacophore mapping

Pharmacophore mapping is a technique used in drug design to identify the essential features a molecule must have to interact effectively with a specific biological target, like a protein. It involves analyzing known active compounds to find common structural elements such as hydrogen bond donors or acceptors, aromatic rings, and charged groups. By creating a 3D template of these features, researchers can screen and design new molecules that fit this pattern, increasing the likelihood of desired biological activity. Essentially, it's a blueprint that guides the creation or discovery of potential drugs based on their key interaction characteristics.