pharmacological saturation

Pharmacological saturation occurs when all the available target receptors in the body are occupied by a drug, meaning no more drug molecules can bind regardless of increasing the dose. At this point, increasing the drug amount doesn't improve its effect because the maximum response has been reached. Essentially, the system is “full,” and additional drug won't produce additional benefit, reflecting a plateau in the drug's efficacy. This concept helps explain why higher doses may not always lead to stronger effects and can also increase the risk of side effects.