Pharmacogenetics of Warfarin

Pharmacogenetics of warfarin involves understanding how a person’s genetic makeup affects their response to the drug. Warfarin is an anticoagulant used to prevent blood clots, but its dose varies widely among individuals. Variations in genes, especially CYP2C9 and VKORC1, influence how quickly the body processes warfarin and how effectively it inhibits clotting. By testing for these genetic differences, doctors can better determine the right starting dose for each patient, reducing the risk of bleeding or clotting complications and improving treatment safety and effectiveness.