Periprosthetic osteolysis

Periprosthetic osteolysis is the process where bone tissue around a joint implant, such as a hip or knee replacement, begins to break down and resorb. This typically occurs due to an immune response to tiny particles released from the artificial joint over time. The body perceives these particles as foreign, triggering inflammation that activates cells which gradually dissolve the surrounding bone. This bone loss can weaken the implant’s stability, potentially leading to loosening or failure of the prosthetic joint, and may require additional medical intervention. Understanding and managing osteolysis are crucial for the longevity of joint replacements.