Peripheral T cell tolerance

Peripheral T cell tolerance is a natural process that prevents immune cells called T cells from attacking the body's own tissues after they have matured and left the thymus. Even if T cells recognize the body's own cells as potentially harmful, mechanisms are in place—such as reducing their activity, inducing them to die, or making them unresponsive—to ensure they do not cause autoimmune diseases. This process helps maintain immune system balance, allowing it to defend against infections while avoiding damage to healthy tissues.