PCSK9 gene

The PCSK9 gene produces a protein that helps regulate LDL cholesterol levels in the blood. This protein influences how the liver removes LDL cholesterol ("bad" cholesterol) from the bloodstream. When PCSK9 activity is high, it reduces the liver's ability to clear LDL, leading to higher cholesterol levels and increased risk of heart disease. Some medicines target this protein to lower cholesterol effectively. Understanding PCSK9 has helped develop new treatments for managing high cholesterol, especially for those who do not respond well to traditional therapies.