PBPK Modeling (Physiologically Based Pharmacokinetic Modeling)

Physiologically Based Pharmacokinetic (PBPK) modeling is a detailed computer simulation used to predict how a drug moves through the human body. It incorporates information about anatomy, blood flow, and how the body absorbs, distributes, metabolizes, and eliminates the drug. By combining biological data with chemical properties, PBPK models help researchers understand drug behavior in different individuals or populations, optimize dosing, and improve safety assessments. Essentially, it’s a sophisticated virtual framework that mimics real physiology to forecast how a drug will behave in various scenarios.