P-glycoprotein

P-glycoprotein is a type of protein found in cell membranes that acts as a drug efflux pump. Its main role is to protect cells by actively transporting certain substances, including many medications and toxins, out of the cell. This process can influence how drugs are absorbed, distributed, and eliminated in the body, affecting their effectiveness. P-glycoprotein is especially significant in organs like the liver, kidneys, and the blood-brain barrier, where it helps prevent harmful substances from reaching sensitive areas, but it can also contribute to drug resistance in treatments like cancer therapy.