outside-out configuration

An outside-out configuration refers to the orientation of neurons in a nerve or nerve-like structure, where the outside surface of the nerve is exposed to the external environment or surrounding tissue, and the internal side is directed inward. In this setup, the nerve’s external markers or sensors face outward, allowing the nerve to detect signals from outside stimuli. This arrangement affects how signals are transmitted and received, often influencing the nerve’s responsiveness and function. It contrasts with inside-out configurations where the internal side faces outward, a distinction important in understanding nerve installation, repair, or experimental setups.