organophosphate syndrome

Organophosphate syndrome results from exposure to organophosphates, chemicals used in pesticides that inhibit an enzyme called acetylcholinesterase. This enzyme normally breaks down acetylcholine, a neurotransmitter involved in nerve signal transmission. When inhibited, acetylcholine accumulates, leading to overstimulation of nerves and resulting in symptoms such as muscle twitching, weakness, excessive salivation, sweating, diarrhea, confusion, and difficulty breathing. Severe cases can cause paralysis, convulsions, or even death. Treatment typically involves administering antidotes like atropine and pralidoxime, which help counteract the excessive nerve stimulation and support recovery.