Optical Clearing Agents

Optical clearing agents are substances applied to biological tissues to make them more transparent. They work by reducing the scattering of light within the tissue, allowing for clearer, deeper imaging with techniques like microscopy or imaging systems. These agents modify the tissue’s refractive index, matching that of the tissue components, which minimizes light distortion. This process enhances the ability to see structures inside tissues more clearly without invasive procedures, aiding in medical diagnosis, research, and imaging. Common agents include glycerol and certain sugars, chosen for their effectiveness and compatibility with biological tissues.