Oncogene BRAF

The BRAF gene produces a protein that helps regulate cell growth and division. When this gene mutates, it can cause the BRAF protein to become overactive, leading to uncontrolled cell growth—an important factor in certain cancers like melanoma, thyroid cancer, and some colorectal cancers. These mutations are known as oncogenic BRAF mutations, and they can drive cancer progression. Targeted therapies that specifically block the faulty BRAF protein have been developed, offering more effective treatments for cancers harboring these mutations. Understanding BRAF’s role helps in diagnosing and creating personalized treatment plans for affected patients.