Nucleotide-binding domain

A Nucleotide-binding domain (NBD) is a specialized part of a protein that temporarily attaches to molecules called nucleotides, like ATP or ADP. These nucleotides supply energy that the protein uses to perform specific tasks, such as transporting substances across cell membranes or helping other proteins change shape. The NBD acts like an energy switch: when the nucleotide binds or releases, it triggers the protein to activate or change its function. This domain is essential for many biological processes, especially in transport proteins and molecular chaperones.